Afadin Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 1q12
Cellular Component:  adherens junction; apical junction complex; apical part of cell; axon; cell junction; cell-cell adherens junction; cell-cell contact zone; cell-cell junction; cytoplasm; cytosol; nuclear speck; nucleoplasm; plasma membrane; somatodendritic compartment; tight junction
Molecular Function:  actin filament binding; cell adhesion molecule binding; LIM domain binding; protein binding; Ras GTPase binding
Biological Process:  adherens junction maintenance; bicellular tight junction assembly; brain morphogenesis; cell adhesion; cell-cell adhesion mediated by cadherin; cerebral cortex development; dendrite arborization; establishment of endothelial intestinal barrier; establishment of protein localization to plasma membrane; homeostasis of number of cells; negative regulation of cell migration; neuroepithelial cell differentiation; positive regulation of cell-cell adhesion; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of dendrite extension; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of mini excitatory postsynaptic potential; protein localization to cell junction; radial glial cell differentiation; regulation of oligodendrocyte progenitor proliferation; regulation of protein localization; signal transduction; telencephalon development
Reference #:  O35889 (UniProtKB)
Alt. Names/Synonyms: Af6; AFAD; Afadin; Afdn; Mllt4; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; Protein Af-6; translocated to, 4
Gene Symbols: Mllt4
Molecular weight: 207,678 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene