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Afadin
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein |
| Chromosomal Location of rat Ortholog: 1q12 |
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Cellular Component:
adherens junction; apical junction complex; apical part of cell; axon; cell junction; cell-cell contact zone; cell-cell junction; cytoplasm; cytosol; excitatory synapse; nuclear speck; nucleoplasm; plasma membrane; pore complex; somatodendritic compartment; tight junction
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Molecular Function:
actin filament binding; cell adhesion molecule binding; LIM domain binding; protein binding; small GTPase binding
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Biological Process:
adherens junction maintenance; bicellular tight junction assembly; brain morphogenesis; cell adhesion; cell-cell adhesion mediated by cadherin; cerebral cortex development; dendrite arborization; establishment of endothelial intestinal barrier; establishment of protein localization to plasma membrane; homeostasis of number of cells; negative regulation of cell migration; neuroepithelial cell differentiation; pore complex assembly; positive regulation of cell-cell adhesion; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of dendrite extension; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of gene expression; positive regulation of mini excitatory postsynaptic potential; protein localization to cell junction; radial glial cell differentiation; regulation of oligodendrocyte progenitor proliferation; regulation of protein localization; signal transduction; telencephalon development
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Reference #:
O35889
(UniProtKB)
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Alt. Names/Synonyms: Af6; AFAD; Afadin; Afdn; Mllt4; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; Protein Af-6; translocated to, 4
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Gene Symbols: Afdn
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Molecular weight:
207,678 Da
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Basal Isoelectric point:
5.82
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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