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ADCY2
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Note: This description may include information from UniProtKB.
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| Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family |
| Chromosomal Location of Human Ortholog: 1p11 |
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Cellular Component:
cytoplasm; dendrite; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane; protein-containing complex
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Molecular Function:
adenylate cyclase activity; adenylate cyclase binding; ATP binding; G-protein beta/gamma-subunit complex binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein binding; protein heterodimerization activity
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cAMP-mediated signaling; cellular response to forskolin; intracellular signal transduction
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Reference #:
P26769
(UniProtKB)
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Alt. Names/Synonyms: Adcy2; adenylate cyclase 2 (brain); Adenylate cyclase type 2; Adenylate cyclase type II; Adenylyl cyclase 2; ATP pyrophosphate-lyase 2
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Gene Symbols: Adcy2
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Molecular weight:
123,316 Da
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Basal Isoelectric point:
8.62
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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NF-kB Signaling
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Parkinson's Disease
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