ADCY2 This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 1p11
Cellular Component:  cytoplasm; dendrite; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane; protein-containing complex
Molecular Function:  adenylate cyclase activity; adenylate cyclase binding; ATP binding; G-protein beta/gamma-subunit complex binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein binding; protein heterodimerization activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cAMP-mediated signaling; cellular response to forskolin; intracellular signal transduction
Reference #:  P26769 (UniProtKB)
Alt. Names/Synonyms: Adcy2; adenylate cyclase 2 (brain); Adenylate cyclase type 2; Adenylate cyclase type II; Adenylyl cyclase 2; ATP pyrophosphate-lyase 2
Gene Symbols: Adcy2
Molecular weight: 123,316 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
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ADCY2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene