CHGA Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Acts as a potent scavenger of free radicals in vitro. May play a role in the regulation of cardiac function and blood pressure. Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. Belongs to the chromogranin/secretogranin protein family. GE-25 is found in the brain. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Secreted; Secreted, signal peptide; Vesicle
Cellular Component:  chromaffin granule; extracellular region; mast cell granule; secretory granule; transport vesicle membrane
Molecular Function:  calcium ion binding
Biological Process:  defense response to fungus; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; innate immune response; killing of cells of other organism; mast cell activation; mast cell chemotaxis; mast cell cytokine production; mast cell degranulation; negative regulation of angiogenesis; negative regulation of catecholamine secretion; negative regulation of hormone secretion; negative regulation of insulin secretion; positive regulation of dense core granule biogenesis; regulation of cell adhesion
Reference #:  P05059 (UniProtKB)
Alt. Names/Synonyms: CHGA; chromogranin A; Chromogranin A precursor; Chromogranin-A; CMGA; Pancreastatin; Pituitary secretory protein I; SP-I
Gene Symbols: CHGA
Molecular weight: 50,015 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
Select Structure to View Below

CHGA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene