ADORA2A
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCRChromosomal Location of human Ortholog: 22q11.23
Cellular Component:
asymmetric synapse; axolemma; dendrite; glutamatergic synapse; intermediate filament; membrane; neuronal cell body; plasma membrane; postsynaptic membrane; presynaptic active zone; presynaptic membrane
Molecular Function:
alpha-actinin binding; enzyme binding; G protein-coupled adenosine receptor activity; identical protein binding; lipid binding; protein binding; protein-containing complex binding; type 5 metabotropic glutamate receptor binding
Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; apoptotic process; apoptotic signaling pathway; astrocyte activation; blood circulation; blood coagulation; cell-cell signaling; cellular defense response; central nervous system development; eating behavior; excitatory postsynaptic potential; G protein-coupled adenosine receptor signaling pathway; inflammatory response; inhibitory postsynaptic potential; locomotory behavior; membrane depolarization; negative regulation of alpha-beta T cell activation; negative regulation of cell population proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of inflammatory response; negative regulation of neuron apoptotic process; negative regulation of protein kinase activity; negative regulation of vascular permeability; neuron projection morphogenesis; phagocytosis; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of apoptotic signaling pathway; positive regulation of circadian sleep/wake cycle, sleep; positive regulation of glutamate secretion; positive regulation of long-term synaptic potentiation; positive regulation of protein secretion; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of urine volume; prepulse inhibition; presynaptic modulation of chemical synaptic transmission; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of calcium ion transport; regulation of DNA-templated transcription; regulation of mitochondrial membrane potential; regulation of norepinephrine secretion; response to amphetamine; response to caffeine; response to inorganic substance; response to purine-containing compound; response to xenobiotic stimulus; sensory perception; synaptic transmission, cholinergic; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; vasodilation
Reference #:
P29274
(UniProtKB)
Alt. Names/Synonyms: A2aR; AA2AR; adenosine A2 receptor; adenosine A2a receptor; Adenosine receptor A2a; adenosine receptor subtype A2a; ADORA2; ADORA2A; hA2aR; RDC8
Gene Symbols: ADORA2A
Molecular weight:
44,707 Da
Basal Isoelectric point:
8.34
Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
Select Structure to View Below
ADORA2A
1MMH - 1=6-36, 2=42-69, 3=78-102, 4=117-143, 5=175-203, 6=233-260, 7=264-296 (human)
1UPE - A=1-304 (human)
2YDO - A=1-317 (human)
2YDV - A=1-317 (human)
3EML - A=222-316 (human)
3PWH - A=1-317 (human)
3QAK - A=222-316 (human)
3REY - A=1-317 (human)
3RFM - A=1-317 (human)
3UZA - A=1-317 (human)
3UZC - A=1-317 (human)
3VG9 - A=1-316 (human)
3VGA - A=1-316 (human)
4EIY - A=219-316 (human)
4UG2 - A/B=1-317 (human)
4UHR - A=1-317 (human)
5G53 - A/B=1-308 (human)
5IU4 - A=219-318 (human)
5IU7 - A=219-315 (human)
5IU8 - A=219-315 (human)
5IUA - A=219-315 (human)
5IUB - A=219-315 (human)
5JTB - A=219-316 (human)
5K2A - A=219-316 (human)
5K2B - A=219-316 (human)
5K2C - A=219-316 (human)
5K2D - A=219-316 (human)
5MZJ - A=219-318 (human)
5MZP - A=219-317 (human)
5N2R - A=234-318 (human)
5NLX - A=219-317 (human)
5NM2 - A=219-317 (human)
5NM4 - A=219-317 (human)
5OLG - A=219-317 (human)
5OLH - A=219-317 (human)
5OLO - A=218-318 (human)
5OLV - A=219-317 (human)
5OLZ - A=219-317 (human)
5OM1 - A=219-317 (human)
5OM4 - A=219-317 (human)
5UIG - A=219-316 (human)
5UVI - A=219-316 (human)
5VRA - A=219-316 (human)
5WF5 - A=222-316 (human)
5WF6 - A=222-316 (human)
6AQF - A=219-316 (human)
6GDG - B=2-340 (human)
6GT3 - A=219-317 (human)
6JZH - A=219-316 (human)
6LPJ - A=219-316 (human)
6LPK - A=219-316 (human)
6LPL - A=219-316 (human)
6MH8 - A=219-316 (human)
6PS7 - A=219-316 (human)
6S0L - A=2-317 (human)
6S0Q - A=219-317 (human)
6WQA - A=219-316 (human)
6ZDR - A=219-317 (human)
6ZDV - A=219-317 (human)
7ARO - A=2-208, A=219-317 (human)
7EZC - A/B=2-208, A/B=219-308 (human)
7PX4 - A=2-208, A=219-316 (human)
7PYR - A=2-208, A=219-316 (human)
7RM5 - A=2-208, A=219-316 (human)
7T32 - A=8-208, A=219-302 (human)
8A2O - A=2-208, A=219-316 (human)
8A2P - A=2-208, A=219-316 (human)
8C9W - A=2-208, A=219-316 (human)
8CIC - A=2-208, A=219-317 (human)
8CU6 - A=2-208, A=219-316 (human)
8CU7 - A=2-208, A=219-316 (human)
8DU3 - A=2-208, A=219-316 (human)
8GNE - A=2-208, A=219-316 (human)
8GNG - A/X=1-316 (human)
8JWY - A=2-208, A=222-316 (human)
8JWZ - A=2-208, A=222-316 (human)
8PWN - A=2-208, A=219-318 (human)
8WDT - A=2-316 (human)
