ADORA2A one of several receptor subtypes for adenosine. A G-protein coupled receptor. Activation is mediated by G proteins which activate adenylyl cyclase. Abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component:  axolemma; dendrite; glutamatergic synapse; Golgi membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; intermediate filament; membrane; neuronal cell body; plasma membrane; postsynaptic density; presynaptic active zone
Molecular Function:  alpha-actinin binding; enzyme binding; G protein-coupled adenosine receptor activity; identical protein binding; protein binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding
Biological Process:  adenosine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; apoptotic process; astrocyte activation; blood circulation; blood coagulation; cell-cell signaling; cellular defense response; cellular protein metabolic process; central nervous system development; eating behavior; excitatory postsynaptic potential; G protein-coupled receptor signaling pathway; inflammatory response; inhibitory postsynaptic potential; locomotory behavior; membrane depolarization; negative regulation of alpha-beta T cell activation; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of inflammatory response; negative regulation of locomotion; negative regulation of neuron apoptotic process; negative regulation of protein kinase activity; negative regulation of vascular permeability; neuron projection morphogenesis; phagocytosis; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of apoptotic signaling pathway; positive regulation of circadian sleep/wake cycle, sleep; positive regulation of glutamate secretion; positive regulation of long-term synaptic potentiation; positive regulation of protein secretion; positive regulation of renal sodium excretion; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of urine volume; prepulse inhibition; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of calcium ion transport; regulation of mitochondrial membrane potential; regulation of norepinephrine secretion; regulation of synaptic vesicle exocytosis; regulation of transcription, DNA-templated; response to amphetamine; response to caffeine; sensory perception; synaptic transmission, cholinergic; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; vasodilation
Reference #:  P29274 (UniProtKB)
Alt. Names/Synonyms: AA2AR; adenosine A2 receptor; adenosine A2a receptor; Adenosine receptor A2a; adenosine receptor subtype A2a; ADORA2; ADORA2A; hA2aR; RDC8
Gene Symbols: ADORA2A
Molecular weight: 44,707 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
Select Structure to View Below

ADORA2A

Protein Structure Not Found.


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