GUCY1A3 Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Protein type: EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc.
Chromosomal Location of Human Ortholog: 3|3 E3
Cellular Component:  cytoplasm; GABA-ergic synapse; glutamatergic synapse; guanylate cyclase complex, soluble; protein-containing complex
Molecular Function:  GTP binding; guanylate cyclase activity; heme binding; ion binding; lyase activity; nucleotide binding; phosphorus-oxygen lyase activity; protein heterodimerization activity
Biological Process:  cGMP biosynthetic process; cyclic nucleotide biosynthetic process; intracellular signal transduction; positive regulation of nitric oxide mediated signal transduction; regulation of blood pressure; relaxation of vascular smooth muscle; response to defense-related host nitric oxide production; retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Reference #:  Q9ERL9 (UniProtKB)
Alt. Names/Synonyms: 1200016O07Rik; alpha 1 sGC; GCS-alpha-1; GCS-alpha-3; GCYA3; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble subunit alpha-1; Guanylate cyclase soluble subunit alpha-3; Gucy1a1; Gucy1a3; Soluble guanylate cyclase large subunit
Gene Symbols: Gucy1a3
Molecular weight: 77,588 Da
Basal Isoelectric point: 6.79  Predict pI for various phosphorylation states
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GUCY1A3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene