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GUCY1A1
a soluble guanylyl cyclase enzyme which interacts with a beta subunit to form the guanylate cyclase enzyme. Activated by nitric oxide. Detected in brain cortex and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. |
| Chromosomal Location of mouse Ortholog: 3|3 E3 |
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Cellular Component:
cytoplasm; GABA-ergic synapse; glutamatergic synapse; guanylate cyclase complex, soluble; protein-containing complex; synapse
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Molecular Function:
adenylate cyclase activity; cytidylate cyclase activity; GTP binding; guanylate cyclase activity; heme binding; ion binding; lyase activity; nucleotide binding; phosphorus-oxygen lyase activity; protein-containing complex binding
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Biological Process:
cGMP biosynthetic process; cGMP-mediated signaling; cyclic nucleotide biosynthetic process; intracellular signal transduction; nitric oxide mediated signal transduction; nitric oxide-cGMP-mediated signaling pathway; positive regulation of nitric oxide mediated signal transduction; regulation of blood pressure; relaxation of vascular associated smooth muscle; response to oxygen levels; retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
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Reference #:
Q9ERL9
(UniProtKB)
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Alt. Names/Synonyms: 1200016O07Rik; alpha 1 sGC; GCS-alpha-1; GCS-alpha-3; GCYA1; GCYA3; guanylate cyclase 1, soluble, alpha 1; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble subunit alpha-1; Guanylate cyclase soluble subunit alpha-3; Gucy1a; Gucy1a1; Gucy1a3; sGC-a; sGC-alpha1; Soluble guanylate cyclase large subunit
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Gene Symbols: Gucy1a1
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Molecular weight:
77,588 Da
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Basal Isoelectric point:
6.79
Predict pI for various phosphorylation states
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