ETB Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 14 E2.3|14 53.05 cM
Cellular Component:  membrane; membrane raft; nuclear membrane; plasma membrane
Molecular Function:  endothelin receptor activity; G protein-coupled receptor activity; peptide hormone binding; protein binding; type 1 angiotensin receptor binding
Biological Process:  aldosterone metabolic process; calcium ion transmembrane transport; calcium-mediated signaling; canonical Wnt signaling pathway; cGMP-mediated signaling; developmental pigmentation; endothelin receptor signaling pathway; enteric nervous system development; enteric smooth muscle cell differentiation; epithelial fluid transport; establishment of endothelial barrier; G protein-coupled receptor signaling pathway; gene expression; heparin metabolic process; I-kappaB kinase/NF-kappaB signaling; macrophage chemotaxis; melanocyte differentiation; negative regulation of apoptotic process; negative regulation of neuron maturation; negative regulation of protein metabolic process; negative regulation of transcription by RNA polymerase II; neural crest cell migration; neuroblast migration; peripheral nervous system development; pharynx development; phospholipase C-activating G protein-coupled receptor signaling pathway; pigmentation; podocyte differentiation; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of penile erection; positive regulation of protein phosphorylation; positive regulation of renal sodium excretion; positive regulation of urine volume; posterior midgut development; protein transmembrane transport; regulation of blood pressure; regulation of epithelial cell proliferation; regulation of fever generation; regulation of heart rate; regulation of pH; regulation of sensory perception of pain; renal albumin absorption; renal sodium excretion; renal sodium ion absorption; renin secretion into blood stream; response to endothelin; response to lipopolysaccharide; response to organic substance; response to pain; response to sodium phosphate; sensory perception of pain; signal transduction; sodium ion homeostasis; vasoconstriction; vasodilation; vein smooth muscle contraction
Reference #:  P48302 (UniProtKB)
Alt. Names/Synonyms: AU022549; Ednrb; Endothelin B receptor; Endothelin receptor non-selective type; Endothelin receptor type B; ET-B; ET-BR; ET>B<; ETb; ETR-; ETR-b; piebald; s; Sox10; Sox10m1
Gene Symbols: Ednrb
Molecular weight: 49,561 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene