TGM1 Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.2.13; Transferase
Chromosomal Location of Human Ortholog: 15p13
Cellular Component:  cell-cell adherens junction; intrinsic component of membrane
Molecular Function:  metal ion binding; protein-glutamine gamma-glutamyltransferase activity
Biological Process:  animal organ morphogenesis; keratinization; keratinocyte differentiation; peptide cross-linking; positive regulation of cell cycle; positive regulation of keratinocyte proliferation
Reference #:  P23606 (UniProtKB)
Alt. Names/Synonyms: Epidermal TGase; Protein-glutamine gamma-glutamyltransferase K; TG(K); TGase K; TGase-1; TGK; Tgm1; transglutaminase 1, K polypeptide; Transglutaminase K; Transglutaminase-1
Gene Symbols: Tgm1
Molecular weight: 90,770 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
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TGM1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene