TGM1
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.3.2.13; Transferase |
Chromosomal Location of rat Ortholog: 15p13 |
Cellular Component:
adherens junction; membrane
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Molecular Function:
identical protein binding; metal ion binding; protein-glutamine gamma-glutamyltransferase activity
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Biological Process:
animal organ morphogenesis; keratinization; keratinocyte differentiation; peptide cross-linking; positive regulation of cell cycle; positive regulation of keratinocyte proliferation
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Reference #:
P23606
(UniProtKB)
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Alt. Names/Synonyms: Epidermal TGase; Protein-glutamine gamma-glutamyltransferase K; TG(K); TGase K; TGase-1; TGK; Tgm1; transglutaminase 1, K polypeptide; Transglutaminase K; Transglutaminase-1
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Gene Symbols: Tgm1
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Molecular weight:
90,770 Da
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Basal Isoelectric point:
6.04
Predict pI for various phosphorylation states
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