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FSHR
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Sertoli cells and ovarian granulosa cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of mouse Ortholog: 17|17 E5 |
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Cellular Component:
cell surface; endosome; membrane; plasma membrane; receptor complex
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Molecular Function:
follicle-stimulating hormone receptor activity; G protein-coupled peptide receptor activity; G protein-coupled receptor activity; peptide hormone binding; protein-hormone receptor activity
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Biological Process:
activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; basement membrane organization; cellular response to follicle-stimulating hormone stimulus; follicle-stimulating hormone signaling pathway; G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway; intracellular water homeostasis; locomotory behavior; male gonad development; negative regulation of bone resorption; neuron projection development; ovarian follicle development; ovulation cycle process; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; primary ovarian follicle growth; regulation of acetylcholine metabolic process; regulation of chromosome organization; regulation of hormone metabolic process; regulation of intracellular estrogen receptor signaling pathway; regulation of MAPK cascade; regulation of osteoclast differentiation; regulation of platelet-derived growth factor receptor signaling pathway; regulation of protein kinase A signaling; regulation of protein phosphorylation; regulation of systemic arterial blood pressure; Sertoli cell development; Sertoli cell proliferation; signal transduction; sperm DNA condensation; spermatid development; spermatogenesis; transcytosis; uterus development
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Reference #:
P35378
(UniProtKB)
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Alt. Names/Synonyms: follicle stimulating hormone receptor; Follicle-stimulating hormone receptor; Follitropin receptor; FSH; FSH-R; Fshr
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Gene Symbols: Fshr
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Molecular weight:
77,769 Da
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Basal Isoelectric point:
6.57
Predict pI for various phosphorylation states
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