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FSHR
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Sertoli cells and ovarian granulosa cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 2p16.3 |
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Cellular Component:
membrane; plasma membrane; receptor complex
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Molecular Function:
follicle-stimulating hormone receptor activity; G protein-coupled peptide receptor activity; protein binding
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Biological Process:
activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to follicle-stimulating hormone stimulus; female gamete generation; female gonad development; follicle-stimulating hormone signaling pathway; G protein-coupled receptor signaling pathway; gonad development; hormone-mediated signaling pathway; male gonad development; positive regulation of ERK1 and ERK2 cascade; positive regulation of phosphatidylinositol 3-kinase signaling; regulation of protein kinase A signaling; spermatogenesis
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Disease: Ovarian Dysgenesis 1; Ovarian Hyperstimulation Syndrome
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Reference #:
P23945
(UniProtKB)
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Alt. Names/Synonyms: follicle stimulating hormone receptor; Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; FSHR; FSHR1; FSHRO; LGR1; MGC141667; MGC141668; ODG1
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Gene Symbols: FSHR
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Molecular weight:
78,238 Da
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Basal Isoelectric point:
6.77
Predict pI for various phosphorylation states
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