CTLA-4 Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q33.2
Cellular Component:  clathrin-coated endocytic vesicle; external side of plasma membrane; Golgi apparatus; integral component of plasma membrane; perinuclear region of cytoplasm; plasma membrane; protein complex involved in cell adhesion
Molecular Function:  protein binding
Biological Process:  adaptive immune response; B cell receptor signaling pathway; cellular response to DNA damage stimulus; immune response; negative regulation of B cell proliferation; negative regulation of immune response; negative regulation of regulatory T cell differentiation; negative regulation of T cell proliferation; positive regulation of apoptotic process; regulation of regulatory T cell differentiation; T cell costimulation
Disease: Autoimmune Lymphoproliferative Syndrome, Type V; Celiac Disease, Susceptibility To, 3; Diabetes Mellitus, Insulin-dependent, 12; Hashimoto Thyroiditis; Systemic Lupus Erythematosus
Reference #:  P16410 (UniProtKB)
Alt. Names/Synonyms: activation-inducible lymphocyte immunomediatory molecule; AILIM; ALPS5; CD; CD152; CD278; celiac disease 3; CELIAC3; CTLA-4; CTLA4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte associated protein 4; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; GRD4; GSE; ICOS; IDDM12; inducible costimulator; inducible T-cell co-stimulator; inducible T-cell costimulator; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; MGC39850
Gene Symbols: CTLA4
Molecular weight: 24,656 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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