PDE4D Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of rat Ortholog: 2q14
Cellular Component:  calcium channel complex; centrosome; cytosol; membrane; myofibril; nucleus; perinuclear region of cytoplasm; plasma membrane; potassium channel complex; protein-containing complex; voltage-gated calcium channel complex
Molecular Function:  3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; ATPase binding; beta-2 adrenergic receptor binding; cAMP binding; cyclic-nucleotide phosphodiesterase activity; enzyme binding; heterocyclic compound binding; metal ion binding; protein binding; scaffold protein binding; transmembrane transporter binding
Biological Process:  adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate; adrenergic receptor signaling pathway; cAMP catabolic process; cAMP-mediated signaling; cellular response to cAMP; cellular response to epinephrine stimulus; cellular response to follicle-stimulating hormone stimulus; cellular response to lipopolysaccharide; establishment of endothelial barrier; lung development; memory; multicellular organism growth; negative regulation of cAMP-mediated signaling; negative regulation of heart contraction; negative regulation of peptidyl-serine phosphorylation; negative regulation of relaxation of cardiac muscle; neutrophil chemotaxis; neutrophil migration; ovulation from ovarian follicle; positive regulation of cell-cell adhesion; positive regulation of interleukin-2 production; positive regulation of interleukin-5 production; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of type II interferon production; protein-containing complex assembly; regulation of cAMP-mediated signaling; regulation of cardiac muscle cell contraction; regulation of G protein-coupled receptor signaling pathway; regulation of heart rate; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; regulation of signaling receptor activity; signal transduction; smooth muscle contraction; T cell receptor signaling pathway
Reference #:  P14270 (UniProtKB)
Alt. Names/Synonyms: cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase splice variant PDE4D8; DPDE3; Pde4d; Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Gene Symbols: Pde4d
Molecular weight: 90,552 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene