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PDE4D
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase |
| Chromosomal Location of mouse Ortholog: 13 D2.1|13 59.69 cM |
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Cellular Component:
calcium channel complex; centrosome; cytoplasm; cytoskeleton; cytosol; membrane; myofibril; nucleus; perinuclear region of cytoplasm; plasma membrane; potassium channel complex; protein-containing complex; voltage-gated calcium channel complex
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Molecular Function:
3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; ATPase binding; beta-2 adrenergic receptor binding; cAMP binding; cyclic-nucleotide phosphodiesterase activity; enzyme binding; heterocyclic compound binding; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; protein binding; scaffold protein binding; transmembrane transporter binding
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Biological Process:
adrenergic receptor signaling pathway; cAMP-mediated signaling; cellular response to cAMP; cellular response to epinephrine stimulus; cellular response to follicle-stimulating hormone stimulus; cellular response to lipopolysaccharide; establishment of endothelial barrier; memory; multicellular organism growth; negative regulation of cAMP-mediated signaling; negative regulation of heart contraction; negative regulation of peptidyl-serine phosphorylation; negative regulation of relaxation of cardiac muscle; neutrophil chemotaxis; neutrophil migration; ovulation from ovarian follicle; positive regulation of cell-cell adhesion; positive regulation of interleukin-2 production; positive regulation of interleukin-5 production; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of type II interferon production; protein-containing complex assembly; regulation of cAMP-mediated signaling; regulation of cardiac muscle cell contraction; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of G protein-coupled receptor signaling pathway; regulation of heart rate; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; regulation of signaling receptor activity; signal transduction; smooth muscle contraction; T cell receptor signaling pathway
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Reference #:
Q01063
(UniProtKB)
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Alt. Names/Synonyms: 9630011N22Rik; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cyclic AMP specific phosphodiesterase PDE4D5A; Dpde; DPDE3; dunc; dunce; Pde4d; phosphodiesterase 4D, cAMP specific
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Gene Symbols: Pde4d
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Molecular weight:
84,563 Da
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Basal Isoelectric point:
4.79
Predict pI for various phosphorylation states
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