AVPR2 Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family
Chromosomal Location of rat Ortholog: Xq37
Cellular Component:  integral component of membrane; integral component of plasma membrane
Molecular Function:  peptide hormone binding; vasopressin receptor activity
Biological Process:  cellular response to hormone stimulus; G protein-coupled receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; interferon-gamma production; negative regulation of renal sodium excretion; negative regulation of urine volume; positive regulation of blood pressure; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; response to cytokine; telencephalon development
Reference #:  Q00788 (UniProtKB)
Alt. Names/Synonyms: Antidiuretic hormone receptor; arginine vasopressin receptor 2; AVPR V2; Avpr2; Renal-type arginine vasopressin receptor; V2R; Vasopressin receptor V2; Vasopressin V2 receptor
Gene Symbols: Avpr2
Molecular weight: 40,749 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene