SHPS1
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Molecular Function: cell-cell adhesion mediator activity; GTPase regulator activity; protein antigen binding; protein binding; protein binding involved in heterotypic cell-cell adhesion; protein phosphatase binding; protein phosphorylated amino acid binding; protein tyrosine kinase binding; SH3 domain binding
Biological Process: actin filament organization; cell migration; cell-matrix adhesion; cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to interleukin-12; cellular response to lipopolysaccharide; cellular response to type II interferon; cytoskeleton organization; granulocyte migration; hematopoietic progenitor cell differentiation; heterotypic cell-cell adhesion; monocyte extravasation; negative regulation of chemokine (C-C motif) ligand 5 production; negative regulation of cytokine production involved in inflammatory response; negative regulation of ERK1 and ERK2 cascade; negative regulation of I-kappaB phosphorylation; negative regulation of inflammatory response; negative regulation of interferon-beta production; negative regulation of interleukin-6 production; negative regulation of JNK cascade; negative regulation of macrophage inflammatory protein 1 alpha production; negative regulation of nitric oxide biosynthetic process; negative regulation of phagocytosis; negative regulation of protein phosphorylation; negative regulation of tumor necrosis factor production; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of phagocytosis; positive regulation of T cell activation; regulation of gene expression; regulation of interleukin-1 beta production; regulation of interleukin-6 production; regulation of nitric oxide biosynthetic process; regulation of tumor necrosis factor production; regulation of type II interferon production
