SNAP-25 a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Part of the SNARE core complex containing SNAP25, VAMP2 and syntaxin 1A. Associates with proteins involved in vesicle docking and membrane fusion. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 2 F3|2 67.56 cM
Cellular Component:  actin cytoskeleton; anchored component of presynaptic membrane; axon; axonal growth cone; cell junction; cytoplasm; cytoskeleton; cytosol; endosome; extrinsic component of cytoplasmic side of plasma membrane; filopodium; glutamatergic synapse; growth cone; intracellular organelle; lamellipodium; membrane; membrane raft; neuron projection; neuronal cell body; perinuclear region of cytoplasm; plasma membrane; postsynapse; presynaptic active zone membrane; presynaptic membrane; SNARE complex; somatodendritic compartment; synapse; synaptic vesicle; synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; trans-Golgi network; voltage-gated potassium channel complex
Molecular Function:  calcium-dependent protein binding; ion channel binding; myosin binding; protein binding; protein domain specific binding; protein N-terminus binding; SNAP receptor activity; SNARE binding; syntaxin binding; syntaxin-1 binding; voltage-gated potassium channel activity
Biological Process:  associative learning; calcium ion-regulated exocytosis of neurotransmitter; endosomal transport; exocytic insertion of neurotransmitter receptor to postsynaptic membrane; exocytosis; locomotory behavior; long-term memory; long-term synaptic potentiation; neurotransmitter receptor internalization; neurotransmitter secretion; positive regulation of hormone secretion; positive regulation of synaptic plasticity; regulation of establishment of protein localization; regulation of neuron projection development; short-term synaptic potentiation; sleep; SNARE complex assembly; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic active zone membrane; synaptic vesicle priming; vesicle fusion
Reference #:  P60879 (UniProtKB)
Alt. Names/Synonyms: Bdr; blind drunk; GENA 70; OTTMUSP00000016582; Snap; SNAP-25; Snap25; SNP25; sp; SUP; Super protein; Synaptosomal-associated 25 kDa protein; Synaptosomal-associated protein 25; synaptosomal-associated protein, 25 kDa
Gene Symbols: Snap25
Molecular weight: 23,315 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SNAP-25

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene