Doublecortin Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: X|X F2
Cellular Component:  axon; axoneme; cell projection; cytoplasm; dendrite; growth cone; microtubule; neuron projection; neuronal cell body
Molecular Function:  microtubule binding; protein binding; protein kinase binding
Biological Process:  axon extension; axoneme assembly; brain development; cell differentiation; central nervous system projection neuron axonogenesis; dendrite morphogenesis; hippocampus development; intracellular signal transduction; layer formation in cerebral cortex; multicellular organism development; nervous system development; neuron migration; photoreceptor cell development; positive regulation of collateral sprouting; positive regulation of endocytosis; pyramidal neuron development; retina development in camera-type eye
Reference #:  O88809 (UniProtKB)
Alt. Names/Synonyms: Dbct; Dcn; Dcx; doublecortex; doublecortin; Doublin; Lis-X; Lissencephalin-X; lissencephaly, X-linked (doublecortin); Neuronal migration protein doublecortin; OTTMUSP00000020397
Gene Symbols: Dcx
Molecular weight: 40,613 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene