Doublecortin Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration. Interacts with tubulin. Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq33-q34
Cellular Component:  axon; axoneme; cytoplasm; cytosol; dendrite; growth cone; neuron projection; neuronal cell body
Molecular Function:  microtubule binding; protein kinase binding
Biological Process:  axon extension; axoneme assembly; brain development; central nervous system projection neuron axonogenesis; dendrite morphogenesis; hippocampus development; intracellular signal transduction; layer formation in cerebral cortex; neuron migration; photoreceptor cell development; positive regulation of collateral sprouting; positive regulation of endocytosis; pyramidal neuron development; response to electrical stimulus; retina development in camera-type eye; spinal cord development
Reference #:  Q9ESI7 (UniProtKB)
Alt. Names/Synonyms: Dcx; doublecortin; Neuronal migration protein doublecortin
Gene Symbols: Dcx
Molecular weight: 40,560 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Doublecortin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene