NEUROD1 Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulates transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor p21Cip1. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Interacts (via helix-loop-helix motif domain) with EP300 (via C-terminus). Heterodimer with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E- box element. Efficient DNA-binding requires dimerization with another bHLH protein. Interacts with RREB1. Interacts with EP300; the interaction is inhibited by NR0B2. Interacts with TCF3; the interaction is inhibited by ID2. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2 C3|2 47.58 cM
Cellular Component:  cytoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; E-box binding; protein binding; protein dimerization activity; protein heterodimerization activity; RNA polymerase II activating transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding
Biological Process:  amacrine cell differentiation; anterior/posterior pattern specification; camera-type eye development; cell differentiation; cell fate commitment; cellular response to glucose stimulus; cerebellum development; dentate gyrus development; embryonic organ morphogenesis; endocrine pancreas development; enteroendocrine cell differentiation; glucose homeostasis; hindbrain development; inner ear development; insulin secretion; multicellular organism development; negative regulation of JAK-STAT cascade; negative regulation of type B pancreatic cell apoptotic process; nervous system development; neuron development; nitric oxide mediated signal transduction; nucleocytoplasmic transport; pancreatic A cell fate commitment; pancreatic PP cell fate commitment; positive regulation of apoptotic process; positive regulation of cell differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; positive regulation of transcription, DNA-templated; regulation of cell cycle arrest; regulation of intestinal epithelial structure maintenance; regulation of neuron differentiation; regulation of transcription, DNA-templated; response to glucose; signal transduction involved in regulation of gene expression
Reference #:  Q60867 (UniProtKB)
Alt. Names/Synonyms: BETA2; BHF-1; bHLHa3; NDF1; Neurod; NeuroD1; neurogenic differentiation 1; Neurogenic differentiation factor 1; OTTMUSP00000014302
Gene Symbols: Neurod1
Molecular weight: 39,999 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NEUROD1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene