|
NEUROD1
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 2 C3|2 47.58 cM |
|
Cellular Component:
cytoplasm; intracellular anatomical structure; nucleus; RNA polymerase II transcription regulator complex
|
|
Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; E-box binding; protein binding; protein dimerization activity; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
|
|
Biological Process:
amacrine cell differentiation; anterior/posterior pattern specification; axon development; camera-type eye development; cell differentiation; cell fate commitment; cellular response to glucose stimulus; cerebellum development; dentate gyrus development; embryonic organ morphogenesis; endocrine pancreas development; enteroendocrine cell differentiation; glucose homeostasis; hindbrain development; inner ear development; insulin secretion; multicellular organism development; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of type B pancreatic cell apoptotic process; nervous system development; nitric oxide mediated signal transduction; nucleocytoplasmic transport; pancreatic A cell fate commitment; pancreatic PP cell fate commitment; positive regulation of apoptotic process; positive regulation of cell differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; receptor signaling pathway via JAK-STAT; regulation of DNA-templated transcription; regulation of intestinal epithelial structure maintenance; regulation of neuron differentiation; response to glucose; sensory organ development; signal transduction involved in regulation of gene expression; transcription by RNA polymerase II
|
|
Reference #:
Q60867
(UniProtKB)
|
|
Alt. Names/Synonyms: Beta-cell E-box transcriptional activator 2; BETA2; BHF-1; bHLH; bHLHa3; Nd1; NDF1; Neu; Neurod; NeuroD1; neurogenic differentiation 1; Neurogenic differentiation factor 1; OTTMUSP00000014302
|
|
Gene Symbols: Neurod1
|
|
Molecular weight:
39,999 Da
|
|
Basal Isoelectric point:
5.22
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
