NEUROD1 Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 2q31.3
Cellular Component:  chromatin; cytoplasm; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
Molecular Function:  chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
Biological Process:  amacrine cell differentiation; anterior/posterior pattern specification; cellular response to glucose stimulus; cerebellum development; dentate gyrus development; embryonic organ morphogenesis; endocrine pancreas development; enteroendocrine cell differentiation; glucose homeostasis; inner ear development; insulin secretion; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of type B pancreatic cell apoptotic process; neurogenesis; neuron development; neuron differentiation; nitric oxide mediated signal transduction; nucleocytoplasmic transport; pancreatic A cell fate commitment; pancreatic PP cell fate commitment; positive regulation of apoptotic process; positive regulation of cell differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; receptor signaling pathway via JAK-STAT; regulation of insulin secretion; regulation of intestinal epithelial structure maintenance; regulation of transcription by RNA polymerase II; response to glucose; response to xenobiotic stimulus; signal transduction involved in regulation of gene expression; transcription by RNA polymerase II
Disease: Diabetes Mellitus, Noninsulin-dependent; Maturity-onset Diabetes Of The Young, Type 6
Reference #:  Q13562 (UniProtKB)
Alt. Names/Synonyms: basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; BETA2; BHF-1; BHLHA3; Class A basic helix-loop-helix protein 3; MODY6; NDF1; NEUROD; NEUROD1; neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD; neuronal differentiation 1; T2D
Gene Symbols: NEUROD1
Molecular weight: 39,920 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene