axin 1 Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Tumor suppressor
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  beta-catenin destruction complex; cell periphery; cytoplasm; cytoplasmic vesicle; cytosol; lateral plasma membrane; nucleus; perinuclear region of cytoplasm
Molecular Function:  armadillo repeat domain binding; beta-catenin binding; enzyme binding; I-SMAD binding; identical protein binding; molecular adaptor activity; protein binding; protein homodimerization activity; protein kinase binding; receptor signaling complex scaffold activity; signaling adaptor activity; SMAD binding; ubiquitin protein ligase binding
Biological Process:  activation of protein kinase activity; apoptotic process; beta-catenin destruction complex assembly; beta-catenin destruction complex disassembly; cellular protein-containing complex assembly; multicellular organism development; negative regulation of canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein catabolic process; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of transcription, DNA-templated; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein transferase activity; regulation of intracellular estrogen receptor signaling pathway; regulation of Wnt signaling pathway; Wnt signaling pathway
Disease: Caudal Duplication Anomaly; Hepatocellular Carcinoma
Reference #:  O15169 (UniProtKB)
Alt. Names/Synonyms: AXIN; axin 1; Axin-1; AXIN1; Axis inhibition protein 1; axis inhibitor 1; AXN1; fused, mouse, homolog of; hAxin; MGC52315
Gene Symbols: AXIN1
Molecular weight: 95,635 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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axin 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein