fascin Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF. Belongs to the fascin family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 7p22.1
Cellular Component:  actin cytoskeleton; cell projection membrane; cell-cell junction; cytoplasm; cytoskeleton; cytosol; filopodium; growth cone; invadopodium; lamellipodium; microspike; microvillus; podosome; ruffle; stress fiber
Molecular Function:  actin binding; actin filament binding; drug binding; protein binding; protein binding, bridging
Biological Process:  actin cytoskeleton organization; actin filament bundle assembly; cell migration; cell motility; cell-cell junction assembly; cytokine-mediated signaling pathway; establishment of apical/basal cell polarity; microspike assembly; positive regulation of extracellular matrix disassembly; positive regulation of filopodium assembly; positive regulation of lamellipodium assembly; positive regulation of podosome assembly; regulation of actin cytoskeleton organization; regulation of microvillus assembly
Reference #:  Q16658 (UniProtKB)
Alt. Names/Synonyms: 55 kDa actin-bundling protein; actin bundling protein; epididymis secretory sperm binding protein; FAN1; Fascin; fascin 1; fascin actin-bundling protein 1; fascin homolog 1, actin-bundling protein; fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus); FLJ38511; FSCN1; HSN; p55; Singed, drosophila, homolog-like; singed-like (fascin homolog, sea urchin); Singed-like protein; SNL
Gene Symbols: FSCN1
Molecular weight: 54,530 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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fascin

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB