| fascin Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF. Belongs to the fascin family. Ubiquitous. Note: This description may include information from UniProtKB. |
| Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 7p22.1 |
| Cellular Component: actin cytoskeleton; cell cortex; cell projection membrane; cell-cell junction; cytoplasm; cytoskeleton; cytosol; filopodium; growth cone; lamellipodium; microspike; microvillus; podosome; ruffle; stress fiber |
| Molecular Function: actin binding; actin filament binding; protein binding; protein-macromolecule adaptor activity |
| Biological Process: actin cytoskeleton organization; actin filament bundle assembly; cell migration; cell motility; cell-cell junction assembly; establishment of apical/basal cell polarity; establishment or maintenance of cell polarity; microspike assembly; parallel actin filament bundle assembly; positive regulation of extracellular matrix disassembly; positive regulation of filopodium assembly; positive regulation of lamellipodium assembly; positive regulation of podosome assembly; regulation of actin cytoskeleton organization; regulation of microvillus assembly |
| Reference #: Q16658 (UniProtKB) |
| Alt. Names/Synonyms: 55 kDa actin-bundling protein; actin bundling protein; epididymis secretory sperm binding protein; FAN1; Fascin; fascin 1; fascin actin-bundling protein 1; fascin homolog 1, actin-bundling protein; fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus); FLJ38511; FSCN1; HSN; p55; Singed, drosophila, homolog-like; singed-like (fascin homolog, sea urchin); Singed-like protein; SNL |
| Gene Symbols: FSCN1 |
| Molecular weight: 54,530 Da |
| Basal Isoelectric point: 6.84 Predict pI for various phosphorylation states |
| CST Pathways: Actin Dynamics |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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fascin |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Protein Atlas
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BioGPS
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Pfam
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