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NKX2-1
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. Belongs to the NK-2 homeobox family. Thyroid and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 14q13.3 |
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Cellular Component:
chromatin; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; intronic transcription regulatory region sequence-specific DNA binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription cis-regulatory region binding
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Biological Process:
anatomical structure formation involved in morphogenesis; axon guidance; brain development; cell differentiation; cerebral cortex cell migration; cerebral cortex GABAergic interneuron differentiation; club cell differentiation; developmental induction; endoderm development; epithelial tube branching involved in lung morphogenesis; forebrain development; forebrain dorsal/ventral pattern formation; forebrain neuron fate commitment; gene expression; globus pallidus development; hippocampus development; hypothalamus development; interneuron migration; Leydig cell differentiation; locomotory behavior; lung development; lung saccule development; negative regulation of cell migration; negative regulation of DNA-templated transcription; negative regulation of epithelial to mesenchymal transition; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; oligodendrocyte differentiation; phospholipid metabolic process; pituitary gland development; positive regulation of circadian rhythm; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to hormone; rhythmic process; thyroid gland development; type II pneumocyte differentiation
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Disease: Chorea, Benign Hereditary; Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction; Thyroid Carcinoma, Papillary
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Reference #:
P43699
(UniProtKB)
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Alt. Names/Synonyms: BCH; BHC; Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2; NK-2 homolog A; NK2 homeobox 1; NKX2-1; NKX2.1; NKX21; NKX2A; NMTC1; T/EBP; TEBP; Thyroid nuclear factor 1; Thyroid transcription factor 1; Thyroid-specific enhancer-binding protein; TITF1; TTF-1; TTF1
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Gene Symbols: NKX2-1
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Molecular weight:
38,596 Da
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Basal Isoelectric point:
9.72
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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