NKX2-1 Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. Belongs to the NK-2 homeobox family. Thyroid and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 14q13.3
Cellular Component:  nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; intronic transcription regulatory region DNA binding; intronic transcription regulatory region sequence-specific DNA binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  anatomical structure formation involved in morphogenesis; axon guidance; brain development; cerebral cortex cell migration; cerebral cortex GABAergic interneuron differentiation; Clara cell differentiation; developmental induction; endoderm development; epithelial tube branching involved in lung morphogenesis; forebrain development; forebrain dorsal/ventral pattern formation; forebrain neuron fate commitment; globus pallidus development; hippocampus development; Leydig cell differentiation; locomotory behavior; lung development; lung saccule development; negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of transforming growth factor beta receptor signaling pathway; neuron migration; oligodendrocyte differentiation; phospholipid metabolic process; pituitary gland development; positive regulation of circadian rhythm; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; response to hormone; rhythmic process; thyroid gland development; type II pneumocyte differentiation
Disease: Chorea, Benign Hereditary; Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction; Thyroid Carcinoma, Papillary
Reference #:  P43699 (UniProtKB)
Alt. Names/Synonyms: BCH; BHC; Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2; NK-2 homolog A; NK2 homeobox 1; NKX2-1; NKX2.1; NKX21; NKX2A; NMTC1; T/EBP; TEBP; Thyroid nuclear factor 1; Thyroid transcription factor 1; Thyroid-specific enhancer-binding protein; TITF1; TTF-1; TTF1
Gene Symbols: NKX2-1
Molecular weight: 38,596 Da
Basal Isoelectric point: 9.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein