FKBP4 Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Chaperone; EC 5.2.1.8; Isomerase
Chromosomal Location of Human Ortholog: 12p13.33
Cellular Component:  axonal growth cone; cytosol; microtubule; mitochondrion; neuronal cell body; nucleoplasm; perinuclear region of cytoplasm; protein-containing complex
Molecular Function:  ATP binding; copper-dependent protein binding; FK506 binding; glucocorticoid receptor binding; GTP binding; heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity; phosphoprotein binding; protein binding; protein binding, bridging; tau protein binding
Biological Process:  androgen receptor signaling pathway; chaperone-mediated protein folding; copper ion transport; embryo implantation; male sex differentiation; negative regulation of microtubule polymerization; negative regulation of microtubule polymerization or depolymerization; negative regulation of neuron projection development; prostate gland development; protein folding; protein-containing complex localization; regulation of cellular response to heat; steroid hormone receptor complex assembly
Reference #:  Q02790 (UniProtKB)
Alt. Names/Synonyms: 52 kD FK506 binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506 binding protein 52; FK506-binding protein 4; FK506-binding protein 4 (59kD); FKBP-4; FKBP-52; FKBP4; FKBP52; FKBP59; HBI; HSP binding immunophilin; HSP-binding immunophilin; Hsp56; Immunophilin FKBP52; p52; p59; p59 protein; Peptidyl-prolyl cis-trans isomerase FKBP4; Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; peptidylprolyl cis-trans isomerase; PPIase FKBP4; T-cell FK506-binding protein, 59kD
Gene Symbols: FKBP4
Molecular weight: 51,805 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FKBP4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB