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TGM1
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.3.2.13; Transferase |
| Chromosomal Location of human Ortholog: 14q12 |
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Cellular Component:
cornified envelope; cytosol; membrane; plasma membrane
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Molecular Function:
identical protein binding; metal ion binding; protein binding; protein-glutamine gamma-glutamyltransferase activity
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Biological Process:
cell envelope organization; keratinization; keratinocyte differentiation; peptide cross-linking; positive regulation of cell cycle; positive regulation of keratinocyte proliferation; protein modification process
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Disease: Ichthyosis, Congenital, Autosomal Recessive 1
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Reference #:
P22735
(UniProtKB)
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Alt. Names/Synonyms: ARCI1; Epidermal TGase; ICR2; K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase; KTG; LI; LI1; Protein-glutamine gamma-glutamyltransferase K; TG(K); TGASE; TGase K; TGase-1; TGK; TGM1; transglutaminase 1; transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Transglutaminase K; transglutaminase, keratinocyte; Transglutaminase-1
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Gene Symbols: TGM1
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Molecular weight:
89,787 Da
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Basal Isoelectric point:
5.68
Predict pI for various phosphorylation states
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