ETB Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component:  plasma membrane
Molecular Function:  endothelin receptor activity; peptide hormone binding
Biological Process:  aldosterone metabolic process; calcium ion transmembrane transport; calcium-mediated signaling; canonical Wnt signaling pathway; endothelin receptor signaling pathway; enteric nervous system development; enteric smooth muscle cell differentiation; establishment of endothelial barrier; gene expression; heparin metabolic process; I-kappaB kinase/NF-kappaB signaling; macrophage chemotaxis; melanocyte differentiation; negative regulation of neuron maturation; negative regulation of protein metabolic process; negative regulation of transcription by RNA polymerase II; neural crest cell migration; neuroblast migration; peripheral nervous system development; pharynx development; podocyte differentiation; posterior midgut development; protein transmembrane transport; regulation of heart rate; regulation of pH; renal albumin absorption; renal sodium excretion; renal sodium ion absorption; renin secretion into blood stream; response to organic substance; response to sodium phosphate; vein smooth muscle contraction
Reference #:  P28088 (UniProtKB)
Alt. Names/Synonyms: EDNRB; endothelin B receptor; Endothelin B receptor precursor; Endothelin receptor Non-selective type; Endothelin receptor type B; ET-B; ETB; ETBR
Gene Symbols: EDNRB
Molecular weight: 49,371 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein