GTF2I Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. Belongs to the TFII-I family. Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; protein binding
Biological Process:  negative regulation of angiogenesis; negative regulation of cytosolic calcium ion concentration; regulation of transcription, DNA-templated; signal transduction; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter
Disease: Williams-beuren Syndrome
Reference #:  P78347 (UniProtKB)
Alt. Names/Synonyms: BAP-135; BAP135; Bruton tyrosine kinase-associated protein 135; BTK-associated protein 135; BTK-associated protein, 135kD; BTKAP1; DIWS; FLJ38776; FLJ56355; General transcription factor II-I; general transcription factor IIi; GTF2I; GTFII-I; IB291; SPIN; SRF-Phox1-interacting protein; TFII-I; WBS; WBSCR6; Williams-Beuren syndrome chromosomal region 6 protein; Williams-Beuren syndrome chromosome region 6
Gene Symbols: GTF2I
Molecular weight: 112,416 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GTF2I

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein