GTF2I a multifunctional phosphoprotein with roles in transcription and signal transduction. Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and Phox1 and interacts cooperatively with Phox1 to promote serum-inducible transcription of a reporter gene driven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Its gene is known to contain at least 34 exons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component:  cell projection; cell soma; nucleoplasm; nucleus
Molecular Function:  DNA binding transcription factor activity; mitogen-activated protein kinase binding; protein binding
Biological Process:  negative regulation of angiogenesis; reduction of cytosolic calcium ion concentration; regulation of transcription from RNA polymerase II promoter; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transition between slow and fast fiber
Disease: Williams-beuren Syndrome
Reference #:  P78347 (UniProtKB)
Alt. Names/Synonyms: BAP-135; BAP135; Bruton tyrosine kinase-associated protein 135; BTK-associated protein 135; BTK-associated protein, 135kD; BTKAP1; DIWS; FLJ38776; FLJ56355; General transcription factor II-I; general transcription factor IIi; GTF2I; GTFII-I; IB291; SPIN; SRF-Phox1-interacting protein; TFII-I; WBS; WBSCR6; Williams-Beuren syndrome chromosomal region 6 protein; Williams-Beuren syndrome chromosome region 6
Gene Symbols: GTF2I
Molecular weight: 112,416 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GTF2I

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein