FKBP4 Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Chaperone; EC 5.2.1.8; Isomerase
Cellular Component: 
Reference #:  P27124 (UniProtKB)
Alt. Names/Synonyms: 52 kDa FK506 binding protein; FK506-binding protein 4; FKB4; FKBP4; FKBP52; FKBP59; HBI; HSP binding immunophilin; HSP56; P59; Peptidyl-prolyl cis-trans isomerase FKBP4
Gene Symbols: FKBP4
Molecular weight: 51,475 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
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FKBP4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene