PDE4D Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of human Ortholog: 5q11.2-q12.1

Cellular Component: apical plasma membrane; calcium channel complex; cytosol; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; voltage-gated calcium channel complex

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; ATPase binding; beta-2 adrenergic receptor binding; cAMP binding; enzyme binding; heterocyclic compound binding; metal ion binding; protein binding; scaffold protein binding; transmembrane transporter binding

Biological Process: adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate; adrenergic receptor signaling pathway; cAMP catabolic process; cAMP-mediated signaling; establishment of endothelial barrier; negative regulation of cAMP-mediated signaling; negative regulation of heart contraction; negative regulation of peptidyl-serine phosphorylation; negative regulation of relaxation of cardiac muscle; positive regulation of interleukin-2 production; positive regulation of interleukin-5 production; positive regulation of type II interferon production; regulation of cardiac muscle cell contraction; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of heart rate; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; regulation of signaling receptor activity; signal transduction; T cell receptor signaling pathway

Reference #: Q08499 (UniProtKB)

Alt. Names/Synonyms: ACRDYS2; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; DKFZp686M11213; DPDE3; dunce-like phosphodiesterase E3; FLJ97311; HSPDE4D; PDE43; PDE4D; PDE4DN2; phosphodiesterase 4D; phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); STRK1; testicular tissue protein Li 136

Gene Symbols: PDE4D

Molecular weight: 91,115 Da

Basal Isoelectric point: 5.31 Predict pI for various phosphorylation states

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PDE4D

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