AFAP1L2 May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation
Chromosomal Location of human Ortholog: 10q25.3
Cellular Component:  cytoplasm; cytosol; plasma membrane
Molecular Function:  protein tyrosine kinase activator activity; SH2 domain binding; SH3 domain binding
Biological Process:  inflammatory response; positive regulation of DNA-templated transcription; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of interleukin-8 production; regulation of interleukin-6 production; regulation of mitotic cell cycle
Reference #:  Q8N4X5 (UniProtKB)
Alt. Names/Synonyms: actin filament associated protein 1 like 2; actin filament associated protein 1-like 2; Actin filament-associated protein 1-like 2; AF1L2; AFAP1-like protein 2; AFAP1L2; CTB-1144G6.4; CTB-1144G6.6; FLJ14564; KIAA1914; XB130
Gene Symbols: AFAP1L2
Molecular weight: 91,300 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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AFAP1L2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein