AFAP1L2
May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Activator; Cell cycle regulation |
Chromosomal Location of human Ortholog: 10q25.3 |
Cellular Component:
cytoplasm; cytosol; plasma membrane
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Molecular Function:
protein tyrosine kinase activator activity; SH2 domain binding; SH3 domain binding
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Biological Process:
inflammatory response; positive regulation of DNA-templated transcription; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of interleukin-8 production; regulation of interleukin-6 production; regulation of mitotic cell cycle
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Reference #:
Q8N4X5
(UniProtKB)
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Alt. Names/Synonyms: actin filament associated protein 1 like 2; actin filament associated protein 1-like 2; Actin filament-associated protein 1-like 2; AF1L2; AFAP1-like protein 2; AFAP1L2; CTB-1144G6.4; CTB-1144G6.6; FLJ14564; KIAA1914; XB130
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Gene Symbols: AFAP1L2
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Molecular weight:
91,300 Da
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Basal Isoelectric point:
5.22
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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