PLD2 May have a role in signal-induced cytoskeletal regulation and/or endocytosis. Belongs to the phospholipase D family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component:  endoplasmic reticulum membrane; plasma membrane; presynapse
Molecular Function:  N-acylphosphatidylethanolamine-specific phospholipase D activity; phosphatidylinositol binding; phospholipase D activity; protein binding
Biological Process:  cytoskeleton organization; Fc-gamma receptor signaling pathway involved in phagocytosis; inositol lipid-mediated signaling; lipid catabolic process; phosphatidic acid biosynthetic process; small GTPase mediated signal transduction; synaptic vesicle recycling
Reference #:  O14939 (UniProtKB)
Alt. Names/Synonyms: Choline phosphatase 2; hPLD2; Phosphatidylcholine-hydrolyzing phospholipase D2; Phospholipase D2; PLD 2; PLD1C; PLD2
Gene Symbols: PLD2
Molecular weight: 105,987 Da
Basal Isoelectric point: 7.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLD2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB