SREBP-2 Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. Belongs to the SREBP family. Ubiquitously expressed in adult and fetal tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor
Chromosomal Location of mouse Ortholog: 15|15 E1
Cellular Component:  cytoplasm; cytoplasmic vesicle; dendrite; endoplasmic reticulum; Golgi apparatus; integral component of membrane; intracellular membrane-bounded organelle; membrane; mitochondrion; nucleoplasm; nucleus; SREBP-SCAP-Insig complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; protein C-terminus binding; protein dimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  cellular response to starvation; cholesterol homeostasis; cholesterol metabolic process; lipid metabolic process; negative regulation of cholesterol efflux; negative regulation of transcription by RNA polymerase II; positive regulation of cholesterol storage; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to hormone; steroid metabolic process
Reference #:  Q3U1N2 (UniProtKB)
Alt. Names/Synonyms: AI608257; bHLHd; bHLHd2; lop13; nuc; Processed sterol regulatory element-binding protein 2; SRBP2; SRE; SREB; Srebf2; SREBP; SREBP-2; Srebp2; SREBP2gc; sterol regulatory element binding factor 2; Sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 2; Transcription factor SREBF2
Gene Symbols: Srebf2
Molecular weight: 122,911 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene