SRPK2 Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); SRPK family
Chromosomal Location of Human Ortholog: 5 A3|5 10.36 cM
Cellular Component:  cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus
Molecular Function:  14-3-3 protein binding; ATP binding; kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  angiogenesis; cell differentiation; intracellular signal transduction; mRNA processing; negative regulation of viral genome replication; nuclear speck organization; phosphorylation; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of viral genome replication; protein phosphorylation; regulation of gene expression; regulation of mRNA processing; RNA splicing; spliceosomal complex assembly
Reference #:  O54781 (UniProtKB)
Alt. Names/Synonyms: AW226533; AW492537; AW547358; mSRPK2; serine/arginine-rich protein specific kinase 2; Serine/arginine-rich protein-specific kinase 2; Serine/threonine-protein kinase SRPK2; SFRS protein kinase 2; SR-protein-specific kinase 2; Srpk2; SRSF protein kinase 2; Wbp6; WW domain binding protein 6
Gene Symbols: Srpk2
Molecular weight: 76,757 Da
Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states
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SRPK2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene