Kv1.1 a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Forms potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well. Channel properties are determined by the combination of alpha chains and modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure. In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation. Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Potassium channels composed of both KCNA1 and KCNA2 appear to play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons. Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction. Required for normal neuromuscular responses. Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli. Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain. Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily. Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons. Detected in the islet of Langerhans. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of rat Ortholog: 4q42
Cellular Component:  apical plasma membrane; axon; axon terminus; calyx of Held; cell junction; cell surface; cytoplasmic vesicle; cytosol; dendrite; endoplasmic reticulum; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; juxtaparanode region of axon; neuronal cell body; paranode region of axon; perikaryon; potassium channel complex; presynaptic membrane; synapse; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity; disordered domain specific binding; protein binding; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated potassium channel activity
Biological Process:  brain development; cell communication by electrical coupling; cellular protein localization; cellular response to magnesium ion; detection of mechanical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of touch; hippocampus development; magnesium ion homeostasis; neuroblast proliferation; neuromuscular process; neuronal action potential; neuronal signal transduction; positive regulation of voltage-gated potassium channel activity; potassium ion transmembrane transport; protein homooligomerization; regulation of membrane potential; regulation of muscle contraction; regulation of postsynaptic membrane potential; regulation of presynaptic membrane potential; startle response
Reference #:  P10499 (UniProtKB)
Alt. Names/Synonyms: IA; Kcna; Kcna1; Kcpvd; Kv1.1; potassium (K+) channel protein voltage dependent; potassium voltage gated channel shaker related subfamily member 1; Potassium voltage-gated channel subfamily A member 1; potassium voltage-gated channel, shaker-related subfamily, member 1; RBKI; RCK1; Voltage-gated potassium channel subunit Kv1.1
Gene Symbols: Kcna1
Molecular weight: 56,379 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene