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NFL
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of rat Ortholog: 15p12 |
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Cellular Component:
axon; axon cytoplasm; cholinergic synapse; cytoplasm; cytosol; growth cone; intermediate filament; neurofilament; neuromuscular junction; neuron projection; postsynapse; postsynaptic intermediate filament cytoskeleton; presynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
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Molecular Function:
identical protein binding; phospholipase binding; protein domain specific binding; protein-containing complex binding; protein-macromolecule adaptor activity; structural constituent of cytoskeleton; structural constituent of postsynaptic intermediate filament cytoskeleton
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Biological Process:
anterograde axonal transport; axonal transport of mitochondrion; axonogenesis; cerebral cortex development; hippocampus development; intermediate filament bundle assembly; intermediate filament organization; intermediate filament polymerization or depolymerization; locomotion; microtubule cytoskeleton organization; motor neuron apoptotic process; negative regulation of motor neuron apoptotic process; neurofilament bundle assembly; neurofilament cytoskeleton organization; neuromuscular process controlling balance; neuron projection morphogenesis; peripheral nervous system axon regeneration; positive regulation of axonogenesis; postsynaptic intermediate filament cytoskeleton organization; postsynaptic modulation of chemical synaptic transmission; protein polymerization; regulation of axon diameter; regulation of synapse maturation; response to acrylamide; response to corticosterone; response to organic substance; response to peptide hormone; response to sodium arsenite; response to toxic substance; retrograde axonal transport; spinal cord development
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Reference #:
P19527
(UniProtKB)
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Alt. Names/Synonyms: 68 kDa neurofilament protein; Nefl; Neurofilament light polypeptide; Neurofilament triplet L protein; neurofilament, light polypeptide; NF-L; Nf68; Nfl
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Gene Symbols: Nefl
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Molecular weight:
61,335 Da
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Basal Isoelectric point:
4.63
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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