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NFL
one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F). Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of Human Ortholog: 15p12 |
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Cellular Component:
axon; axon cytoplasm; cholinergic synapse; cytoplasm; growth cone; intermediate filament; neurofilament; neuromuscular junction; neuron projection; postsynaptic intermediate filament cytoskeleton; presynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
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Molecular Function:
identical protein binding; phospholipase binding; protein binding, bridging; protein C-terminus binding; protein domain specific binding; protein heterodimerization activity; structural constituent of cytoskeleton; structural constituent of postsynaptic intermediate filament cytoskeleton
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Biological Process:
anterograde axonal transport; axonal transport of mitochondrion; cerebral cortex development; hippocampus development; intermediate filament bundle assembly; intermediate filament organization; intermediate filament polymerization or depolymerization; locomotion; microtubule cytoskeleton organization; negative regulation of neuron apoptotic process; neurofilament bundle assembly; neurofilament cytoskeleton organization; neuromuscular process controlling balance; neuron projection morphogenesis; peripheral nervous system axon regeneration; positive regulation of axonogenesis; postsynaptic intermediate filament cytoskeleton organization; protein polymerization; regulation of axon diameter; response to acrylamide; response to corticosterone; response to organic substance; response to peptide hormone; response to sodium arsenite; response to toxic substance; retrograde axonal transport; spinal cord development; synapse maturation
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Reference #:
P19527
(UniProtKB)
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Alt. Names/Synonyms: 68 kDa neurofilament protein; Nefl; Neurofilament light polypeptide; Neurofilament triplet L protein; neurofilament, light polypeptide; NF-L; Nf68; Nfl
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Gene Symbols: Nefl
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Molecular weight:
61,335 Da
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Basal Isoelectric point:
4.63
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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