NFL Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of rat Ortholog: 15p12
Cellular Component:  axon; axon cytoplasm; cholinergic synapse; cytoplasm; cytosol; growth cone; intermediate filament; neurofilament; neuromuscular junction; neuron projection; postsynapse; postsynaptic intermediate filament cytoskeleton; presynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
Molecular Function:  identical protein binding; phospholipase binding; protein domain specific binding; protein-containing complex binding; protein-macromolecule adaptor activity; structural constituent of cytoskeleton; structural constituent of postsynaptic intermediate filament cytoskeleton
Biological Process:  anterograde axonal transport; axonal transport of mitochondrion; axonogenesis; cerebral cortex development; hippocampus development; intermediate filament bundle assembly; intermediate filament organization; intermediate filament polymerization or depolymerization; locomotion; microtubule cytoskeleton organization; motor neuron apoptotic process; negative regulation of motor neuron apoptotic process; neurofilament bundle assembly; neurofilament cytoskeleton organization; neuromuscular process controlling balance; neuron projection morphogenesis; peripheral nervous system axon regeneration; positive regulation of axonogenesis; postsynaptic intermediate filament cytoskeleton organization; postsynaptic modulation of chemical synaptic transmission; protein polymerization; regulation of axon diameter; regulation of synapse maturation; response to acrylamide; response to corticosterone; response to organic substance; response to peptide hormone; response to sodium arsenite; response to toxic substance; retrograde axonal transport; spinal cord development
Reference #:  P19527 (UniProtKB)
Alt. Names/Synonyms: 68 kDa neurofilament protein; Nefl; Neurofilament light polypeptide; Neurofilament triplet L protein; neurofilament, light polypeptide; NF-L; Nf68; Nfl
Gene Symbols: Nefl
Molecular weight: 61,335 Da
Basal Isoelectric point: 4.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFL

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene