NFL one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F). Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 15p12
Cellular Component:  axon; axon cytoplasm; cholinergic synapse; cytoplasm; growth cone; intermediate filament; neurofilament; neuromuscular junction; neuron projection; postsynaptic intermediate filament cytoskeleton; presynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
Molecular Function:  identical protein binding; phospholipase binding; protein binding, bridging; protein C-terminus binding; protein domain specific binding; protein heterodimerization activity; structural constituent of cytoskeleton; structural constituent of postsynaptic intermediate filament cytoskeleton
Biological Process:  anterograde axonal transport; axonal transport of mitochondrion; cerebral cortex development; hippocampus development; intermediate filament bundle assembly; intermediate filament organization; intermediate filament polymerization or depolymerization; locomotion; microtubule cytoskeleton organization; negative regulation of neuron apoptotic process; neurofilament bundle assembly; neurofilament cytoskeleton organization; neuromuscular process controlling balance; neuron projection morphogenesis; peripheral nervous system axon regeneration; positive regulation of axonogenesis; postsynaptic intermediate filament cytoskeleton organization; protein polymerization; regulation of axon diameter; response to acrylamide; response to corticosterone; response to organic substance; response to peptide hormone; response to sodium arsenite; response to toxic substance; retrograde axonal transport; spinal cord development; synapse maturation
Reference #:  P19527 (UniProtKB)
Alt. Names/Synonyms: 68 kDa neurofilament protein; Nefl; Neurofilament light polypeptide; Neurofilament triplet L protein; neurofilament, light polypeptide; NF-L; Nf68; Nfl
Gene Symbols: Nefl
Molecular weight: 61,335 Da
Basal Isoelectric point: 4.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NFL

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene