Kv3.4 This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component:  axon terminus; neuromuscular junction; plasma membrane
Molecular Function:  potassium channel activity; protein binding
Biological Process:  chemical synaptic transmission; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport; regulation of neurotransmitter secretion
Reference #:  Q03721 (UniProtKB)
Alt. Names/Synonyms: HKSHIIIC; KCNC4; KSHIIIC; KV3.4; MGC126818; Potassium voltage-gated channel subfamily C member 4; potassium voltage-gated channel, Shaw-related subfamily, member 4; Shaw-related voltage-gated potassium channel protein 4; Voltage-gated potassium channel subunit Kv3.4
Gene Symbols: KCNC4
Molecular weight: 69,767 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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