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IL8RB
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine |
| Chromosomal Location of mouse Ortholog: 1 C3|1 38.41 cM |
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Cellular Component:
cell surface; external side of plasma membrane; mast cell granule; membrane; microtubule cytoskeleton; mitotic spindle; nucleoplasm; plasma membrane
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Molecular Function:
C-C chemokine binding; C-C chemokine receptor activity; C-X-C chemokine receptor activity; chemokine receptor activity; G protein-coupled receptor activity; interleukin-8 binding; interleukin-8 receptor activity; protein binding
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Biological Process:
acute inflammatory response to antigenic stimulus; calcium-mediated signaling; cell surface receptor signaling pathway; cellular defense response; chemokine-mediated signaling pathway; chemotaxis; G protein-coupled receptor signaling pathway; immune response; interleukin-8-mediated signaling pathway; metanephric tubule morphogenesis; negative regulation of apoptotic process; negative regulation of neutrophil apoptotic process; neutrophil activation; neutrophil chemotaxis; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of leukocyte chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of vascular permeability; receptor internalization; signal transduction
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Reference #:
P35343
(UniProtKB)
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Alt. Names/Synonyms: C-X-C chemokine receptor type 2; CD128; CD182; CDw128; chemokine (C-X-C motif) receptor 2; chemokine (C-X-C) receptor 2; Cmka; Cmkar2; CXC-R2; CXCR-2; Cxcr2; Gpcr; Gpcr16; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-; IL-8 receptor alpha chain; IL-8R B; IL-8rb; IL-8Rh; IL8RA; Il8rb; interleukin 8 receptor, beta; interleukin-8 receptor type B; mIL-8RH
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Gene Symbols: Cxcr2
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Molecular weight:
40,425 Da
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Basal Isoelectric point:
8.94
Predict pI for various phosphorylation states
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