AVPR2 Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family
Chromosomal Location of human Ortholog: Xq28
Cellular Component:  clathrin-coated vesicle membrane; endoplasmic reticulum; endosome; Golgi apparatus; integral component of membrane; plasma membrane
Molecular Function:  protein binding; vasopressin receptor activity
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; excretion; G protein-coupled receptor signaling pathway; hemostasis; I-kappaB kinase/NF-kappaB signaling; interferon-gamma production; membrane organization; negative regulation of renal sodium excretion; negative regulation of urine volume; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of protein ubiquitination; positive regulation of systemic arterial blood pressure; renal water homeostasis; response to cytokine; telencephalon development
Disease: Diabetes Insipidus, Nephrogenic, X-linked; Nephrogenic Syndrome Of Inappropriate Antidiuresis
Reference #:  P30518 (UniProtKB)
Alt. Names/Synonyms: ADHR; Antidiuretic hormone receptor; arginine vasopressin receptor 2; AVPR V2; AVPR2; DI1; DIR; DIR3; MGC126533; MGC138386; NDI; Renal-type arginine vasopressin receptor; V2R; Vasopressin V2 receptor
Gene Symbols: AVPR2
Molecular weight: 40,279 Da
Basal Isoelectric point: 9.49  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene