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AVPR2
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family |
| Chromosomal Location of human Ortholog: Xq28 |
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Cellular Component:
clathrin-coated vesicle membrane; endoplasmic reticulum; endosome; Golgi apparatus; integral component of membrane; plasma membrane
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Molecular Function:
protein binding; vasopressin receptor activity
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Biological Process:
activation of adenylate cyclase activity; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; excretion; G protein-coupled receptor signaling pathway; hemostasis; I-kappaB kinase/NF-kappaB signaling; interferon-gamma production; membrane organization; negative regulation of renal sodium excretion; negative regulation of urine volume; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of protein ubiquitination; positive regulation of systemic arterial blood pressure; renal water homeostasis; response to cytokine; telencephalon development
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Disease: Diabetes Insipidus, Nephrogenic, X-linked; Nephrogenic Syndrome Of Inappropriate Antidiuresis
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Reference #:
P30518
(UniProtKB)
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Alt. Names/Synonyms: ADHR; Antidiuretic hormone receptor; arginine vasopressin receptor 2; AVPR V2; AVPR2; DI1; DIR; DIR3; MGC126533; MGC138386; NDI; Renal-type arginine vasopressin receptor; V2R; Vasopressin V2 receptor
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Gene Symbols: AVPR2
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Molecular weight:
40,279 Da
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Basal Isoelectric point:
9.49
Predict pI for various phosphorylation states
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