Nlp Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Microtubule-binding
Chromosomal Location of Human Ortholog: 20p11.21
Cellular Component:  cytosol; intercellular bridge; microtubule
Molecular Function:  calcium ion binding; protein binding
Biological Process:  ciliary basal body-plasma membrane docking; G2/M transition of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle
Reference #:  Q9Y2I6 (UniProtKB)
Alt. Names/Synonyms: dJ691N24.1; FLJ11792; KIAA0980; ninein like; ninein-like; Ninein-like protein; NINL; NLP
Gene Symbols: NINL
Molecular weight: 156,344 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein