PKAR1A Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Belongs to the cAMP-dependent kinase regulatory chain family. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 10q32.1
Cellular Component:  axoneme; cAMP-dependent protein kinase complex; cytoplasm; cytosol; glutamatergic synapse; immunological synapse; neuromuscular junction; nucleotide-activated protein kinase complex; plasma membrane raft; protein-containing complex; synapse
Molecular Function:  3',5'-cyclic-GMP phosphodiesterase activity; cAMP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; protein binding; protein domain specific binding; protein kinase A catalytic subunit binding; ubiquitin protein ligase binding
Biological Process:  cardiac muscle cell proliferation; cGMP-mediated signaling; female meiotic nuclear division; heart development; mesoderm formation; negative regulation of activated T cell proliferation; negative regulation of cAMP-dependent protein kinase activity; negative regulation of meiotic nuclear division; negative regulation of protein kinase activity; regulation of meiotic cell cycle process involved in oocyte maturation; regulation of protein kinase activity; sarcomere organization
Reference #:  P09456 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase type I-alpha regulatory subunit; Prkar1a; protein kinase, cAMP dependent regulatory, type I, alpha; Protein kinase, cAMP dependent, regulatory, type 1; RIIA
Gene Symbols: Prkar1a
Molecular weight: 43,095 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKAR1A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene