PKAR1A Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Belongs to the cAMP-dependent kinase regulatory chain family. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 17q24.2
Cellular Component:  cAMP-dependent protein kinase complex; ciliary base; cytoplasm; cytosol; glutamatergic synapse; neuromuscular junction; nucleotide-activated protein kinase complex; plasma membrane raft; protein-containing complex
Molecular Function:  cAMP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; protein binding; protein domain specific binding; protein kinase A catalytic subunit binding; ubiquitin protein ligase binding
Biological Process:  activation of protein kinase A activity; blood coagulation; cardiac muscle cell proliferation; cellular response to glucagon stimulus; female meiotic nuclear division; intracellular signal transduction; mesoderm formation; negative regulation of activated T cell proliferation; negative regulation of cAMP-dependent protein kinase activity; negative regulation of meiotic nuclear division; regulation of transcription by RNA polymerase II; renal water homeostasis; sarcomere organization
Disease: Acrodysostosis 1 With Or Without Hormone Resistance; Carney Complex, Type 1; Myxoma, Intracardiac; Pigmented Nodular Adrenocortical Disease, Primary, 1
Reference #:  P10644 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; cAMP-dependent protein kinase type I-alpha regulatory subunit; CAR; CNC; CNC1; DKFZp779L0468; KAP0; MGC17251; PKR1; PPNAD1; PRKAR1; PRKAR1A; protein kinase A type 1a regulatory subunit; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1); Tissue-specific extinguisher 1; TSE1
Gene Symbols: PRKAR1A
Molecular weight: 42,982 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKAR1A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein