TXA2-R Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component:  acrosomal vesicle; integral component of membrane; membrane; nuclear speck; plasma membrane
Molecular Function:  G protein-coupled receptor activity; thromboxane A2 receptor activity; thromboxane receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to lipopolysaccharide; G protein-coupled receptor signaling pathway; inflammatory response; negative regulation of cell migration involved in sprouting angiogenesis; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of blood pressure; positive regulation of cytosolic calcium ion concentration; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction; regulation of vasoconstriction; response to lipopolysaccharide; second-messenger-mediated signaling; signal transduction
Reference #:  P30987 (UniProtKB)
Alt. Names/Synonyms: MGC107665; Prostanoid TP receptor; TA2R; Tbxa2r; Thromboxane A2 receptor; thromboxane prostanoid; TP; Tp receptor; TXA2; TXA2 receptor; TXA2-R
Gene Symbols: Tbxa2r
Molecular weight: 37,098 Da
Basal Isoelectric point: 10.29  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene