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H1R
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of mouse Ortholog: 6 E3|6 53.05 cM |
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Cellular Component:
cytosol; dendrite; membrane; plasma membrane
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Molecular Function:
calcium ion transmembrane transporter activity; G protein-coupled receptor activity; G protein-coupled serotonin receptor activity; histamine binding; histamine receptor activity; neurotransmitter receptor activity
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Biological Process:
calcium ion import; cellular response to histamine; chemical synaptic transmission; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; manganese ion transmembrane transport; memory; negative regulation of steroid biosynthetic process; positive regulation of nitric oxide biosynthetic process; positive regulation of vasoconstriction; regulation of synaptic plasticity; regulation of vascular permeability; rhythmic process; signal transduction; visual learning
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Reference #:
P70174
(UniProtKB)
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Alt. Names/Synonyms: Bordetella pertussis induced histamine sensitization; Bphs; H1R; HH1R; Hir; Histamine H1 receptor; histamine receptor H1; Hrh1
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Gene Symbols: Hrh1
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Molecular weight:
55,682 Da
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Basal Isoelectric point:
9.43
Predict pI for various phosphorylation states
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