hnRNP H1
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). Expressed ubiquitously. Note: This description may include information from UniProtKB.
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Protein type: RNA splicing; RNA-binding; Spliceosome |
Chromosomal Location of mouse Ortholog: 11|11 B1.3 |
Cellular Component:
catalytic step 2 spliceosome; cytosol; nucleoplasm; nucleus; postsynaptic density; ribonucleoprotein complex; spliceosomal complex
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Molecular Function:
enzyme binding; identical protein binding; nucleic acid binding; protein binding; RNA binding
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Biological Process:
cellular response to interleukin-7; mRNA processing; regulation of RNA splicing; RNA splicing
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Reference #:
O35737
(UniProtKB)
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Alt. Names/Synonyms: AI642080; E430005G16Rik; Heterogeneous nuclear ribonucleoprotein H; Heterogeneous nuclear ribonucleoprotein H, N-terminally processed; Heterogeneous nuclear ribonucleoprotein H1; Heterogeneous nuclear ribonucleoprotein H1, isoform CRA_d; Hnr; HNRH1; hnRNP H; hnRNP H1; Hnrnph; Hnrnph1; Hnrph; Hnrph1; OTTMUSP00000005745
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Gene Symbols: Hnrnph1
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Molecular weight:
49,199 Da
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Basal Isoelectric point:
5.89
Predict pI for various phosphorylation states
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