SGK2 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); SGK family
Chromosomal Location of Human Ortholog: 2|2 H2
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; potassium channel regulator activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  intracellular signal transduction; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation
Reference #:  Q9QZS5 (UniProtKB)
Alt. Names/Synonyms: AI098171; AW146006; OTTMUSP00000001094; Serine/threonine-protein kinase Sgk2; serum/glucocorticoid regulated kinase 2; serum/glucocorticoid regulated kinase-like; Serum/glucocorticoid-regulated kinase 2; Sgk2; Sgkl
Gene Symbols: Sgk2
Molecular weight: 41,359 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SGK2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene