TESK1 Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.1; Kinase, protein; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, dual-specificity (non-receptor); TESK subfamily; TKL group
Chromosomal Location of mouse Ortholog: 4|4 A5
Cellular Component:  cell projection; centrosome; cytoplasm; cytoplasmic vesicle; cytoskeleton; nucleus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  actin cytoskeleton organization; establishment of vesicle localization; negative regulation of cilium assembly; negative regulation of phosphorylation; negative regulation of protein autophosphorylation; negative regulation of protein serine/threonine kinase activity; phosphorylation; podocyte cell migration; positive regulation of protein localization to nucleus; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of protein localization
Reference #:  O70146 (UniProtKB)
Alt. Names/Synonyms: AI326901; Dual specificity testis-specific protein kinase 1; OTTMUSP00000007229; Tesk1; Testicular protein kinase 1; testis specific protein kinase 1
Gene Symbols: Tesk1
Molecular weight: 68,052 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Select Structure to View Below

TESK1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene