NEK8 Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor)
Chromosomal Location of human Ortholog: 17q11.2
Cellular Component:  ciliary base; ciliary inversin compartment; cilium; cytoplasm; cytoskeleton
Molecular Function:  ATP binding; metal ion binding; protein binding
Biological Process:  animal organ morphogenesis; determination of left/right symmetry; heart development; protein phosphorylation; regulation of hippo signaling
Disease: Nephronophthisis 9; Renal-hepatic-pancreatic Dysplasia 2
Reference #:  Q86SG6 (UniProtKB)
Alt. Names/Synonyms: JCK; MGC138445; NEK12A; NEK8; nephrocystin 9; Never in mitosis A-related kinase 8; NIMA (never in mitosis gene a)- related kinase 8; NIMA related kinase 8; NIMA-family kinase NEK8; NIMA-related kinase 12a; Nima-related protein kinase 12a; NimA-related protein kinase 8; NPHP9; RHPD2; Serine/threonine-protein kinase Nek8; serine/thrionine-protein kinase NEK8
Gene Symbols: NEK8
Molecular weight: 74,806 Da
Basal Isoelectric point: 8.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene