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eNOS
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. Belongs to the NOS family. Platelets, placenta, liver and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase |
| Chromosomal Location of rat Ortholog: 4q11 |
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Cellular Component:
apical part of cell; caveola; cytoplasm; cytoskeleton; cytosol; Golgi apparatus; nucleus; plasma membrane; sarcolemma
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Molecular Function:
actin binding; actin monomer binding; arginine binding; beta-catenin binding; cadherin binding; calmodulin binding; flavin adenine dinucleotide binding; FMN binding; heme binding; Hsp90 protein binding; metal ion binding; NADP binding; nitric-oxide synthase activity; nitric-oxide synthase binding; protein binding; scaffold protein binding; tetrahydrobiopterin binding
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Biological Process:
angiogenesis; aortic valve morphogenesis; arginine catabolic process; blood vessel diameter maintenance; blood vessel remodeling; bone development; calcium ion transport; cellular response to cAMP; cellular response to growth factor stimulus; cellular response to heat; cellular response to high density lipoprotein particle stimulus; cellular response to insulin stimulus; cellular response to low-density lipoprotein particle stimulus; cellular response to magnesium ion; cellular response to mechanical stimulus; cellular response to organic cyclic compound; cellular response to rotenone; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; endocardial cushion morphogenesis; endothelial cell migration; establishment of localization in cell; female pregnancy; homeostasis of number of cells within a tissue; in utero embryonic development; lipopolysaccharide-mediated signaling pathway; lung development; negative regulation of biomineral tissue development; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of cell population proliferation; negative regulation of hydrolase activity; negative regulation of muscle hyperplasia; negative regulation of potassium ion transport; negative regulation of smooth muscle cell proliferation; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; ovulation from ovarian follicle; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of blood vessel endothelial cell migration; positive regulation of gene expression; positive regulation of guanylate cyclase activity; potassium ion transport; pulmonary valve morphogenesis; regulation of apoptotic process; regulation of nervous system process; regulation of sodium ion transport; regulation of systemic arterial blood pressure by endothelin; regulation of the force of heart contraction by chemical signal; removal of superoxide radicals; response to activity; response to amino acid; response to axon injury; response to carbohydrate; response to corticosterone; response to cytokine; response to erythropoietin; response to estradiol; response to ethanol; response to fluid shear stress; response to fructose; response to hormone; response to hyperoxia; response to hypoxia; response to ketone; response to L-arginine; response to lead ion; response to lipopolysaccharide; response to magnetism; response to mechanical stimulus; response to mercury ion; response to metal ion; response to nicotine; response to nutrient levels; response to organic cyclic compound; response to peptide; response to peptide hormone; response to salt; response to ultrasound; response to xenobiotic stimulus; retina development in camera-type eye; smooth muscle hyperplasia; vasodilation; ventricular septum morphogenesis
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Reference #:
Q62600
(UniProtKB)
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Alt. Names/Synonyms: cNOS; Constitutive NOS; EC-NOS; endothelial nitric oxide synthase 3; Endothelial NOS; eNOS; Nitric oxide synthase 3; nitric oxide synthase 3, endothelial cell; Nitric oxide synthase, endothelial; NOS type III; Nos3; NOSIII
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Gene Symbols: Nos3
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Molecular weight:
133,290 Da
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Basal Isoelectric point:
6.8
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Angiogenesis
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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