GABRB3 Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity. The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. Plays an important role in somatosensation and in the production of antinociception. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1q22
Cellular Component:  cell junction; chloride channel complex; cytoplasmic vesicle membrane; GABA-A receptor complex; GABA-ergic synapse; inhibitory synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of postsynaptic specialization membrane; neuron projection; plasma membrane; postsynapse; synapse; terminal bouton
Molecular Function:  AP-2 adaptor complex binding; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; GABA-gated chloride ion channel activity; identical protein binding; protein binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  cellular response to histamine; chemical synaptic transmission; chloride transmembrane transport; cochlea development; gamma-aminobutyric acid signaling pathway; inhibitory postsynaptic potential; inhibitory synapse assembly; inner ear receptor cell development; innervation; ion transmembrane transport; negative regulation of neuron apoptotic process; negative regulation of neuron death; nervous system process; neuron development; regulation of membrane potential; regulation of neuron apoptotic process; roof of mouth development; sensory perception of sound; signal transduction; synaptic transmission, GABAergic
Reference #:  NP_058761 (RefSeq)
Alt. Names/Synonyms: GABA(A) receptor subunit beta-3; Gabrb3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; Gamma-aminobutyric acid receptor beta 3; gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid receptor, subunit beta 3; Testis gamma-aminobutyric acid receptor subunit beta 3
Gene Symbols: Gabrb3
Molecular weight: 54,184 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene