GABRB1 Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 14p11
Cellular Component:  cell junction; chloride channel complex; cytoplasm; dendrite; GABA-A receptor complex; GABA-ergic synapse; integral component of plasma membrane; membrane; neuron projection; nuclear envelope; nucleus; plasma membrane; postsynaptic membrane; receptor complex; synapse
Molecular Function:  anion channel activity; GABA receptor binding; GABA-A receptor activity; GABA-gated chloride ion channel activity; ligand-gated ion channel activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  cellular response to histamine; central nervous system neuron development; chemical synaptic transmission; chloride transmembrane transport; chloride transport; gamma-aminobutyric acid signaling pathway; ion transmembrane transport; ion transport; nervous system process; ovulation cycle; regulation of membrane potential; regulation of postsynaptic membrane potential; response to progesterone; response to toxic substance; signal transduction
Reference #:  P15431 (UniProtKB)
Alt. Names/Synonyms: GABA(A) receptor subunit beta-1; Gabrb-1; Gabrb1; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1; Gamma-aminobutyric acid receptor beta 1; Gamma-aminobutyric acid receptor subunit beta-1; gamma-aminobutyric acid receptor, subunit beta 1; GARB1; GBRB1
Gene Symbols: Gabrb1
Molecular weight: 54,072 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
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GABRB1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene