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NCX1
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family |
| Chromosomal Location of human Ortholog: 2p22.1 |
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Cellular Component:
axon; axon terminus; cell periphery; dendrite; intercalated disc; neuronal cell body; nucleoplasm; plasma membrane; postsynapse; postsynaptic density; sarcolemma; synapse; T-tubule; Z disc
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Molecular Function:
ankyrin binding; calcium ion binding; calcium:sodium antiporter activity; calmodulin binding; cytoskeletal protein binding; protein binding; transmembrane transporter binding
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Biological Process:
calcium ion homeostasis; calcium ion import; calcium ion import across plasma membrane; calcium ion transmembrane import into cytosol; calcium ion transmembrane transport; calcium ion transport into cytosol; cardiac muscle cell development; cardiac muscle contraction; cell communication by electrical coupling involved in cardiac conduction; cellular response to caffeine; intracellular calcium ion homeostasis; intracellular sodium ion homeostasis; membrane depolarization during cardiac muscle cell action potential; monoatomic ion transport; muscle contraction; negative regulation of cytosolic calcium ion concentration; negative regulation of protein serine/threonine kinase activity; positive regulation of bone mineralization; positive regulation of the force of heart contraction; regulation of cardiac conduction; regulation of cardiac muscle contraction by calcium ion signaling; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cell communication by electrical coupling; regulation of gene expression; regulation of heart rate; regulation of the force of heart contraction; relaxation of cardiac muscle; relaxation of smooth muscle; response to muscle stretch; sodium ion import across plasma membrane; sodium ion transmembrane transport; vascular associated smooth muscle contraction
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Reference #:
P32418
(UniProtKB)
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Alt. Names/Synonyms: CNC; DKFZp779F0871; FLJ37694; FLJ43417; MGC119581; Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; NAC1; NCX1; SLC8A1; Sodium/calcium exchanger 1; solute carrier family 8 (sodium/calcium exchanger), member 1; Solute carrier family 8 member 1; solute carrier family 8 member A1
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Gene Symbols: SLC8A1
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Molecular weight:
108,547 Da
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Basal Isoelectric point:
4.91
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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